2025-03-18-24_articles_updated

期刊: Nature Methods

标题: 空间机械转录组学计算流程

英文标题: A computational pipeline for spatial mechano-transcriptomics

链接: https://www.nature.com/articles/s41592-025-02618-1

期刊: Nature Communications

标题: 内分泌-外分泌miR-503-322通过靶向腺泡细胞中的MKNK1驱动与衰老相关的胰腺炎

英文标题: Endocrine-exocrine miR-503-322 drives aging-associated pancreatitis via targeting MKNK1 in acinar cells

链接: https://www.nature.com/articles/s41467-025-57615-x

期刊: Computational biology and bioinformatics : nature.com subject feeds

标题: 全面大规模的生物医学知识图谱，用于人工智能驱动的数据驱动生物医学研究

英文标题: A comprehensive large-scale biomedical knowledge graph for AI-powered data-driven biomedical research

链接: https://www.nature.com/articles/s42256-025-01014-w

期刊: Computational biology and bioinformatics : nature.com subject feeds

标题: 揭示可解释人工智能中的敏感和决定性模式：几何深度学习案例分析

英文标题: Towards unveiling sensitive and decisive patterns in explainable AI with a case study in geometric deep learning

链接: https://www.nature.com/articles/s42256-025-00998-9

期刊: Computational biology and bioinformatics : nature.com subject feeds

标题: 空间机械转录组学计算流程

英文标题: A computational pipeline for spatial mechano-transcriptomics

链接: https://www.nature.com/articles/s41592-025-02618-1

期刊: Nature Genetics

标题: 棉花的端粒到端粒基因组组装揭示了着丝粒进化和短季适应的见解

英文标题: A telomere-to-telomere genome assembly of cotton provides insights into centromere evolution and short-season adaptation

链接: https://www.nature.com/articles/s41588-025-02130-4

期刊: Nature Genetics

标题: 对1,325个茶树品种的基因组分析揭示了茶叶植物改良的农艺和代谢特性

英文标题: Genomic analysis of 1,325 Camellia accessions sheds light on agronomic and metabolic traits for tea plant improvement

链接: https://www.nature.com/articles/s41588-025-02135-z

期刊: Nature Genetics

标题: 跨族系和按性别分层全基因组关联分析杏仁核和亚核体积

英文标题: Cross-ancestry and sex-stratified genome-wide association analyses of amygdala and subnucleus volumes

链接: https://www.nature.com/articles/s41588-025-02136-y

期刊: bioRxiv Subject Collection: Bioinformatics

标题: MCMC-CE：一种用于估计二次形式小右尾概率的新颖且高效算法，在基因组学中的应用

英文标题: MCMC-CE: A Novel and Efficient Algorithm for Estimating Small Right-Tail Probabilities of Quadratic Forms with Applications in Genomics

链接: https://www.biorxiv.org/content/10.1101/2025.03.16.643492v1?rss=1

期刊: bioRxiv Subject Collection: Bioinformatics

标题: 一种用于泛癌蛋白质组学数据整合的新型算法

英文标题: A Novel Algorithm for the Harmonization of Pan-cancer Proteomics

链接: https://www.biorxiv.org/content/10.1101/2025.03.17.642820v1?rss=1

期刊: bioRxiv Subject Collection: Bioinformatics

标题: 高效率地推断50种复杂人类性状共有的蛋白质组结构似然

英文标题: High-efficiency likelihood inference of shared proteomic architectures across 50 complex human traits

链接: https://www.biorxiv.org/content/10.1101/2025.03.16.643065v1?rss=1

期刊: bioRxiv Subject Collection: Bioinformatics

标题: 通过关系嵌入重建元路径进行药物再利用

英文标题: Drug Repurposing through Meta-path Reconstruction using Relationship Embedding

链接: https://www.biorxiv.org/content/10.1101/2025.03.15.641108v1?rss=1

期刊: bioRxiv Subject Collection: Bioinformatics

标题: 深度对比特征压缩结合经典机器学习，通过高效筛选大型化学库实现配体发现

英文标题: Deep contrastive feature compression with classical machine learning enables ligand discovery through efficient triage of large chemical libraries

链接: https://www.biorxiv.org/content/10.1101/2025.03.16.643501v1?rss=1

期刊: bioRxiv Subject Collection: Bioinformatics

标题: 探究全基因组图中倒位拓扑基序

英文标题: Investigating the topological motifs of inversions in pangenome graphs

链接: https://www.biorxiv.org/content/10.1101/2025.03.14.643331v1?rss=1

期刊: bioRxiv Subject Collection: Bioinformatics

标题: 多视角深度学习显著提高高度复杂数据与临床结果关联性

英文标题: Multi-view deep learning of highly multiplexed imaging data improves association of cell states with clinical outcomes

链接: https://www.biorxiv.org/content/10.1101/2025.03.14.643377v1?rss=1

期刊: bioRxiv Subject Collection: Bioinformatics

标题: 一种用于检测和解析基因-性状关联的转录组广域关联研究的替代框架

英文标题: An alternative framework for transcriptome-wide association studies to detect and decipher gene-trait associations

链接: https://www.biorxiv.org/content/10.1101/2025.03.14.643391v1?rss=1

期刊: bioRxiv Subject Collection: Bioinformatics

标题: 一种古老的、无需参考的联合推断现代人类基因组中尼安德特人和丹尼索瓦人入侵片段的方法

英文标题: An archaic reference-free method to jointly infer Neanderthal and Denisovan introgressed segments in modern human genomes

链接: https://www.biorxiv.org/content/10.1101/2025.03.17.643330v1?rss=1

期刊: bioRxiv Subject Collection: Bioinformatics

标题: Tresor：一个集成平台，用于模拟具有真实PCR错误表示的转录组读数，涵盖各种RNA测序技术

英文标题: Tresor: An integrated platform for simulating transcriptomic reads with realistic PCR error representation across various RNA sequencing technologies

链接: https://www.biorxiv.org/content/10.1101/2025.03.15.643015v1?rss=1

期刊: bioRxiv Subject Collection: Bioinformatics

标题: CAdir：通过CA空间中的方向进行快速聚类和可视化单细胞转录组数据

英文标题: CAdir: Fast Clustering and Visualization of Single-Cell Transcriptomics Data by Direction in CA Space

链接: https://www.biorxiv.org/content/10.1101/2025.03.14.643234v1?rss=1

期刊: bioRxiv Subject Collection: Bioinformatics

标题: scRAPID-web：一个用于从单细胞转录组预测蛋白质-RNA相互作用的网络服务器

英文标题: scRAPID-web: a web server for predicting protein-RNA interactions from single-cell transcriptomics

链接: https://www.biorxiv.org/content/10.1101/2025.03.12.642785v1?rss=1

期刊: JAMA Network Open New Online

标题: 减少孕期尿液药物筛查的危害

英文标题: Reducing the Harm of Urine Drug Screening in Pregnancy

链接: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2831655

期刊: JAMA Network Open New Online

标题: 构建生物库以推动生物医学研究和基于基因组信息的护理

英文标题: Building Biobanks to Drive Biomedical Research and Genomically Informed Care

链接: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2831654

期刊: JAMA Network Open New Online

标题: 劳动和分娩中尿液药物筛查政策的种族平等

英文标题: Racial Equity in Urine Drug Screening Policies in Labor and Delivery

链接: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2831646

期刊: JAMA Network Open New Online

标题: 基因组筛查在一个单一卫生系统内

英文标题: Genomic Screening at a Single Health System

链接: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2831645