A genetically synthetic protein-based cationic polymer for siRNA delivery
Liu, Y., Jia, Z., Li, L., & Chen, F. (2011). A genetically synthetic protein-based cationic polymer for siRNA delivery. Medical Hypotheses, 76(2), 239-240.
CV
Education
- B.S. in Biotechnology, Northwest University, 2006-2010
- M.S. in Biomedical Engineering, National University of Defense Technology, 2010-2013
- Visiting Student in Bioinformatics, The William Harvey Research Institute, QMUL 2014-2016
- Ph.D in Biomedical Engineering, National University of Defense Technology, 2013-2016
Work experience
- 2016-2022: Assistant Professor
- 2022-: Associate Professor
Research Interests
- Drug repositioning
- Omics
Publications
Application of ribosome profiling
Jia, Z.L., Qu, W.B., Lu, Y.M., Luo, Z.G., & Zhang, C.G. (2013). Application of ribosome profiling 核糖体谱技术及其应用. Progress in Biochemistry and Biophysics, 40(1), 30-32.
Gene Ranking of RNA-Seq Data via Discriminant Non-Negative Matrix Factorization
Jia, Z., Zhang, X., Guan, N., Bo, X., Barnes, M.R., & Luo, Z. (2015). Gene Ranking of RNA-Seq Data via Discriminant Non-Negative Matrix Factorization. PLos One, 10(9), e0137782.
Gene Ranking of RNA-Seq Data via Discriminant Non-Negative Matrix Factorization
Jia, Z., Zhang, X., Guan, N., Bo, X., Barnes, M.R., & Luo, Z. (2015). Gene Ranking of RNA-Seq Data via Discriminant Non-Negative Matrix Factorization. PLos One, 10(9), e0137782.
Semi-Supervised Projective Non-Negative Matrix Factorization for Cancer Classification
Zhang, X., Guan, N., Jia, Z., Qiu, X., & Luo, Z. (2015). Semi-Supervised Projective Non-Negative Matrix Factorization for Cancer Classification. PLos One, 10(9), e0138814.
Health and population effects of rare gene knockouts in adult humans with related parents
Narasimhan, V.M., Hunt, K.A., Mason, D., Baker, C.L., Karczewski, K.J., Barnes, M.E.R., …& van, H.D.A. (2016). Health and population effects of rare gene knockouts in adult humans with related parents. Science, 352(6284), 474-477.
Cogena, a novel tool for co-expressed gene-set enrichment analysis, applied to drug repositioning and drug mode of action discovery
Jia, Z., Liu, Y., Guan, N., Bo, X., Luo, Z., & Barnes, M.R. (2016). Cogena, a novel tool for co-expressed gene-set enrichment analysis, applied to drug repositioning and drug mode of action discovery. BMC Genomics, 17, 414.
High Expression of CPT1A Predicts Adverse Outcomes: A Potential Therapeutic Target for Acute Myeloid Leukemia
Shi, J., Fu, H., Jia, Z., He, K., Fu, L., & Wang, W. (2016). High Expression of CPT1A Predicts Adverse Outcomes: A Potential Therapeutic Target for Acute Myeloid Leukemia. EBioMedicine, 14, 55-64.
The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle
Ren, M., Ng, F.L., Warren, H.R., Witkowska, K., Baron, M., Jia, Z., …& Caulfield, M.J. (2018). The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle.. Hum Mol Genet, 27(1), 199-210.
Transcriptional profiling in the livers of rats after hypobaric hypoxia exposure
Xu, Z., Jia, Z., Shi, J., Zhang, Z., Gao, X., Jia, Q., …& He, K. (2019). Transcriptional profiling in the livers of rats after hypobaric hypoxia exposure. PeerJ, 7, e6499.
Time-Course Transcriptome Analysis for Drug Repositioning in Fusobacterium nucleatum-Infected Human Gingival Fibroblasts.
Kang, W., Jia, Z., Tang, D., Zhao, X., Shi, J., Jia, Q., …& Feng, Q. (2019). Time-Course Transcriptome Analysis for Drug Repositioning in Fusobacterium nucleatum-Infected Human Gingival Fibroblasts. Frontiers in Cell and Developmental Biology, 7, UNSP 204.
Fusobacterium nucleatum Facilitates Apoptosis, ROS Generation, and Inflammatory Cytokine Production by Activating AKT/MAPK and NF-kappa B Signaling Pathways in Human Gingival Fibroblasts.
Kang, W., Jia, Z., Tang, D., Zhang, Z., Gao, H., He, K., & Feng, Q. (2019). Fusobacterium nucleatum Facilitates Apoptosis, ROS Generation, and Inflammatory Cytokine Production by Activating AKT/MAPK and NF-kappa B Signaling Pathways in Human Gingival Fibroblasts. Oxidative Medicine and Cellular Longevity, 2019, 1681972.
Impacts of the plateau environment on the gut microbiota and blood clinical indexes in Han and Tibetan individuals
Jia Z, Zhao X, Liu X, Zhao L, Jia Q, Shi J, Xu X, Hao L, Xu Z, Zhong Q, Yu K, Cui S, Chen H, Guo J, Li X, Han Y, Song X, Zhao C, Bo X, Tian Y, Wang W, Xie G, Feng Q, He K. 2020. Impacts of the plateau environment on the gut microbiota and blood clinical indexes in Han and Tibetan individuals. mSystems 5:e00660-19. https://doi.org/10.1128/mSystems.00660-19.
Heightened innate immune responses in the respiratory tract of COVID-19 patients
Zhou, Zhuo, Lili Ren, Li Zhang, Jiaxin Zhong, Yan Xiao, Zhilong Jia, Li Guo et al. "Heightened innate immune responses in the respiratory tract of COVID-19 patients." Cell Host & Microbe (2020).
Transcriptome-based drug repositioning for coronavirus disease 2019 (COVID-19)
Jia, Z., Song, X., Shi, J., Wang, W., & He, K. (2020). Transcriptome-based drug repositioning for coronavirus disease 2019 (COVID-19). Volume 78, Issue 4, June 2020, ftaa036, Pathogens and Disease.
Transcriptional landscape in rat intestines under hypobaric hypoxia
Tian L, Jia Z, Xu Z, Shi J, Zhao X, He K. 2021. Transcriptional landscape in rat intestines under hypobaric hypoxia. PeerJ 9:e11823
The active lung microbiota landscape of COVID-19 patients through the metatranscriptome data analysis
Han Y, Jia Z, Shi J, Wang W, He K. 2021. The active lung microbiota landscape of COVID-19 patients through the metatranscriptome data analysis. BioImpacts 10.34172/bi.2021.23378
Proteomic and clinical biomarkers for acute mountain sickness in a longitudinal cohort
Yang, J., Jia, Z., Song, X. et al. Proteomic and clinical biomarkers for acute mountain sickness in a longitudinal cohort. Commun Biol 5, 548 (2022). https://doi.org/10.1038/s42003-022-03514-6
Low-dose of caffeine alleviates high altitude pulmonary edema via regulating mitochondrial quality control process in AT1 cells
Tian, L., Jia, Z., Yan, Y., Jia, Q., Shi, W., Cui, S., Chen, H., Han, Y., Zhao, X., & He, K. (2023). Low-dose of caffeine alleviates high altitude pulmonary edema via regulating mitochondrial quality control process in AT1 cells. Frontiers in pharmacology, 14, 1155414. https://doi.org/10.3389/fphar.2023.1155414
Structural variants involved in high-altitude adaptation detected using single-molecule long-read sequencing
Shi, J., Jia, Z., Sun, J. et al. Structural variants involved in high-altitude adaptation detected using single-molecule long-read sequencing. Nat Commun 14, 8282 (2023). https://doi.org/10.1038/s41467-023-44034-z
Talks
Drug repositioning based on coexpressed gene-set enrichment analysis (cogena)
Conference proceedings talk at European Bioconductor Developers' Conference 2015, Cambridge
Co-expressed gene-set enrichment analysis for drug repositioning with examples of psoriasis and periodontal diseases
Conference proceedings talk at The 4th Big Data Forum for Life and Health Sciences 2019, Beijing
Transcriptome-based drug repositioning for COVID-19
Conference proceedings talk at World biological science and technology conference 2021 BioST virtual 2021, virtual