High Expression of CPT1A Predicts Adverse Outcomes: A Potential Therapeutic Target for Acute Myeloid Leukemia
Published in EBioMedicine, 2016
Recommended citation: Shi, J., Fu, H., Jia, Z., He, K., Fu, L., & Wang, W. (2016). High Expression of CPT1A Predicts Adverse Outcomes: A Potential Therapeutic Target for Acute Myeloid Leukemia. EBioMedicine, 14, 55-64. http://zhilongjia.github.io/files/2016_AML.pdf
Identification of prognostic biomarkers is essential for therapeutic choice of AML. This study represents direct evidences that high expression of CPT1A is significantly associated with poor outcomes and abnormal genomic and epigenomic patterns in AML patients. CPT1A is an important catalyzer for fatty-acid oxidation pathway, which may provide alternative carbon source for leukemia proliferation. Findings of this study may indicate the significance of fat metabolism in leukemogenesis.
Recommended citation: Shi, J., Fu, H., Jia, Z., He, K., Fu, L., & Wang, W. (2016). High Expression of CPT1A Predicts Adverse Outcomes: A Potential Therapeutic Target for Acute Myeloid Leukemia. EBioMedicine, 14, 55-64.