Transcriptome-based drug repositioning for COVID-19
Date:
Cogena-based drug repositioning is less computationally intensive than docking methods.
- The transcriptome-based drug screening that identified drugs that are capable of restoring virus-induced gene expression dysregulation, rather than directly targeting viral or human proteins, as is the case for classical molecule docking methods. Esp. dexamethasone.
- We identified two antiviral drugs (saquinavir and ribavirin) and several other candidate drugs (such as dinoprost, dipivefrine, dexamethasone and (-)-isoprenaline).
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