2025-03-29-22_articles_updated

期刊: Nature Methods

标题: 使用Orbitrap Astral质谱仪进行去噪搜索，将人类血浆中代谢物和暴露组注释的数量翻倍

英文标题: Denoising Search doubles the number of metabolite and exposome annotations in human plasma using an Orbitrap Astral mass spectrometer

链接: https://www.nature.com/articles/s41592-025-02646-x

期刊: Nature Methods

标题: 基于配体MPNN的原子上下文条件蛋白质序列设计

英文标题: Atomic context-conditioned protein sequence design using LigandMPNN

链接: https://www.nature.com/articles/s41592-025-02626-1

期刊: Computational biology and bioinformatics : nature.com subject feeds

标题: 通过迁移学习在全癌症基因组中特定元素背景突变率的估计

英文标题: Element-specific estimation of background mutation rates in whole cancer genomes through transfer learning

链接: https://www.nature.com/articles/s41698-025-00871-3

期刊: Computational biology and bioinformatics : nature.com subject feeds

标题: 整合社会经济剥夺指数和电子健康记录数据以预测抗菌药物耐药性

英文标题: Integrating socioeconomic deprivation indices and electronic health record data to predict antimicrobial resistance

链接: https://www.nature.com/articles/s44259-025-00090-7

期刊: Computational biology and bioinformatics : nature.com subject feeds

标题: 教程：针对人群规模关联分析的全外显子和全基因组测序数据质量过滤指南

英文标题: Tutorial: guidelines for quality filtering of whole-exome and whole-genome sequencing data for population-scale association analyses

链接: https://www.nature.com/articles/s41596-025-01169-1

期刊: Computational biology and bioinformatics : nature.com subject feeds

标题: 基于配体MPNN的原子级条件蛋白质序列设计

英文标题: Atomic context-conditioned protein sequence design using LigandMPNN

链接: https://www.nature.com/articles/s41592-025-02626-1

期刊: Computational biology and bioinformatics : nature.com subject feeds

标题: 大规模人微生物群生物合成分析揭示了多样化的保护性核糖体肽

英文标题: Large-scale biosynthetic analysis of human microbiomes reveals diverse protective ribosomal peptides

链接: https://www.nature.com/articles/s41467-025-58280-w

期刊: Computational biology and bioinformatics : nature.com subject feeds

标题: 使用Orbitrap Astral质谱仪，去噪搜索将人类血浆中代谢物和暴露组注释的数量翻倍

英文标题: Denoising Search doubles the number of metabolite and exposome annotations in human plasma using an Orbitrap Astral mass spectrometer

链接: https://www.nature.com/articles/s41592-025-02646-x

期刊: Computational biology and bioinformatics : nature.com subject feeds

标题: 转录组学在长读长测序时代

英文标题: Transcriptomics in the era of long-read sequencing

链接: https://www.nature.com/articles/s41576-025-00828-z

期刊: Computational biology and bioinformatics : nature.com subject feeds

标题: 评估1099种血浆代谢物对2099个二元疾病终点的潜在因果效应

英文标题: Assessing the potential causal effects of 1099 plasma metabolites on 2099 binary disease endpoints

链接: https://www.nature.com/articles/s41467-025-58129-2

期刊: AAAS: Science: Table of Contents

标题: 端粒转座子在线性细菌基因组中普遍存在

英文标题: Telomeric transposons are pervasive in linear bacterial genomes

链接: https://www.science.org/doi/abs/10.1126/science.adp1973?af=R

期刊: AAAS: Science: Table of Contents

标题: 马匹中运行遗传“停止”信号加速氧气代谢和能量生产

英文标题: Running a genetic stop sign accelerates oxygen metabolism and energy production in horses

链接: https://www.science.org/doi/abs/10.1126/science.adr8589?af=R

期刊: AAAS: Science: Table of Contents

标题: 犬类全基因组关联研究确定DENND1B为犬类和人类的肥胖基因

英文标题: Canine genome-wide association study identifies DENND1B as an obesity gene in dogs and humans

链接: https://www.science.org/doi/abs/10.1126/science.ads2145?af=R

期刊: AAAS: Science Advances: Table of Contents

标题: 异源合成生物学：延缓衰老和与衰老相关疾病的潜在工具

英文标题: Xenotopic synthetic biology: Prospective tools for delaying aging and age-related diseases

链接: https://www.science.org/doi/abs/10.1126/sciadv.adu1710?af=R

期刊: AAAS: Science Advances: Table of Contents

标题: μSonic-hand：由声学气-液-固相互作用驱动的生物医学微操作

英文标题: μSonic-hand: Biomedical micromanipulation driven by acoustic gas-liquid-solid interactions

链接: https://www.science.org/doi/abs/10.1126/sciadv.ads8167?af=R

期刊: AAAS: Science Advances: Table of Contents

标题: 类固醇激素水平随性别、年龄、生活方式和遗传而变化

英文标题: Steroid hormone levels vary with sex, aging, lifestyle, and genetics

链接: https://www.science.org/doi/abs/10.1126/sciadv.adu6094?af=R

期刊: AAAS: Science Advances: Table of Contents

标题: 昼夜节律通过调节锌饥饿响应和次级代谢对真菌致病性至关重要

英文标题: Circadian clock is critical for fungal pathogenesis by regulating zinc starvation response and secondary metabolism

链接: https://www.science.org/doi/abs/10.1126/sciadv.ads1341?af=R

期刊: AAAS: Science Advances: Table of Contents

标题: 一种双重化学药物负载的透明质酸纳米凝胶，通过破坏溶酶体稳态诱导难治性急性髓系白血病（AML）的分化治疗

英文标题: A dual chemodrug-loaded hyaluronan nanogel for differentiation induction therapy of refractory AML via disrupting lysosomal homeostasis

链接: https://www.science.org/doi/abs/10.1126/sciadv.ado3923?af=R

期刊: bioRxiv Subject Collection: Bioinformatics

标题: ARGContextProfiler：利用组装图提取和评分抗生素耐药基因的基因组背景

英文标题: ARGContextProfiler: Extracting and Scoring the Genomic Contexts of Antibiotic Resistance Genes using Assembly Graphs

链接: https://www.biorxiv.org/content/10.1101/2025.03.24.645075v1?rss=1

期刊: bioRxiv Subject Collection: Bioinformatics

标题: 基于空间意识的调整兰德指数用于评估空间转录组聚类

英文标题: Spatially Aware Adjusted Rand Index for Evaluating Spatial Transcriptomics Clustering

链接: https://www.biorxiv.org/content/10.1101/2025.03.25.645156v1?rss=1

期刊: bioRxiv Subject Collection: Bioinformatics

标题: SpaBatch：使用图深度学习进行空间转录组数据的批量对齐

英文标题: SpaBatch: Batch Alignment of Spatial Transcriptomics Data using Graph Deep Learning

链接: https://www.biorxiv.org/content/10.1101/2025.03.24.645150v1?rss=1

期刊: bioRxiv Subject Collection: Bioinformatics

标题: QuickProt：一种基于DIA和PRM质谱技术的蛋白质组学数据集的生物信息学和可视化工具

英文标题: QuickProt: A bioinformatics and visualization tool for DIA and PRM mass spectrometry-based proteomics datasets

链接: https://www.biorxiv.org/content/10.1101/2025.03.24.645047v1?rss=1