2025-03-30-6_articles_updated

期刊: Nature Communications

标题: 基因组规模CRISPRi筛选鉴定出pcnB抑制基因，赋予大肠杆菌提高游离脂肪酸产量的生理优势

英文标题: Genome-scale CRISPRi screen identifies pcnB repression conferring improved physiology for overproduction of free fatty acids in Escherichia coli

链接: https://www.nature.com/articles/s41467-025-58368-3

期刊: Nature Communications

标题: 高效准确的基因组-wide基因-环境相互作用分析大规模生物样本库框架

英文标题: Efficient and accurate framework for genome-wide gene-environment interaction analysis in large-scale biobanks

链接: https://www.nature.com/articles/s41467-025-57887-3

期刊: Computational biology and bioinformatics : nature.com subject feeds

标题: 增强基因组分析中核苷酸序列表示的对比优化

英文标题: Enhancing nucleotide sequence representations in genomic analysis with contrastive optimization

链接: https://www.nature.com/articles/s42003-025-07902-6

期刊: Computational biology and bioinformatics : nature.com subject feeds

标题: 通过迁移学习在整体癌症基因组中估计特定元素的背景突变率

英文标题: Element-specific estimation of background mutation rates in whole cancer genomes through transfer learning

链接: https://www.nature.com/articles/s41698-025-00871-3

期刊: bioRxiv Subject Collection: Bioinformatics

标题: MetaboMiNR：一个专注于代谢和核受体的无标签定量蛋白质组学实验分析的在线应用程序

英文标题: MetaboMiNR: a web application to analyze label free quantitative proteomic experiments with a focus on metabolism and nuclear receptors

链接: https://www.biorxiv.org/content/10.1101/2025.03.25.644590v1?rss=1

期刊: bioRxiv Subject Collection: Bioinformatics

标题: 揭示使用核方法研究HIV蛋白酶耐药性和遗传多样性的机制

英文标题: Unraveling HIV protease drug resistance and genetic diversity with kernel methods

链接: https://www.biorxiv.org/content/10.1101/2025.03.26.644092v1?rss=1