2025-04-19-13_articles_updated

期刊: Computational biology and bioinformatics : nature.com subject feeds

标题: 孤儿疾病的治疗靶点预测：整合全基因组关联研究和转录组关联研究

英文标题: Therapeutic target prediction for orphan diseases integrating genome-wide and transcriptome-wide association studies

链接: https://www.nature.com/articles/s41467-025-58464-4

期刊: Computational biology and bioinformatics : nature.com subject feeds

标题: 利用机器学习引导的半自动化培养基优化揭示盐是假单胞菌Pseudomonas putida中flaviolin生产的关键因素

英文标题: Machine learning-led semi-automated medium optimization reveals salt as key for flaviolin production in Pseudomonas putida

链接: https://www.nature.com/articles/s42003-025-08039-2

期刊: Computational biology and bioinformatics : nature.com subject feeds

标题: UnitedMet利用RNA-代谢物共变异性来推断临床样本中的代谢物水平

英文标题: UnitedMet harnesses RNA–metabolite covariation to impute metabolite levels in clinical samples

链接: https://www.nature.com/articles/s43018-025-00943-0

期刊: Nature Medicine

标题: 蛋白质组学揭示不平等衰老之谜

英文标题: Proteomics sheds light on unequal aging

链接: https://www.nature.com/articles/s41591-025-03657-z

期刊: AAAS: Science: Table of Contents

标题: 反复利用复杂结构基因组变异的适应性

英文标题: Adaptation repeatedly uses complex structural genomic variation

链接: https://www.science.org/doi/abs/10.1126/science.adp3745?af=R

期刊: AAAS: Science: Table of Contents

标题: 深部组织转录组学和亚细胞高空间分辨率成像

英文标题: Deep-tissue transcriptomics and subcellular imaging at high spatial resolution

链接: https://www.science.org/doi/abs/10.1126/science.adq2084?af=R

期刊: AAAS: Science Advances: Table of Contents

标题: 慢性BCR信号在衰老和自身免疫中无反应B细胞分化为与年龄相关的B细胞中的关键作用

英文标题: Critical roles of chronic BCR signaling in the differentiation of anergic B cells into age-associated B cells in aging and autoimmunity

链接: https://www.science.org/doi/abs/10.1126/sciadv.adt8199?af=R

期刊: AAAS: Science Advances: Table of Contents

标题: 由线粒体功能障碍引起的代谢重编程促进mTORC1依赖性的骨骼衰老

英文标题: Metabolic rewiring caused by mitochondrial dysfunction promotes mTORC1-dependent skeletal aging

链接: https://www.science.org/doi/abs/10.1126/sciadv.ads1842?af=R

期刊: AAAS: Science Advances: Table of Contents

标题: 通过深度挖掘宏基因组模式工程化噬菌体

英文标题: Engineering bacteriophages through deep mining of metagenomic motifs

链接: https://www.science.org/doi/abs/10.1126/sciadv.adt6432?af=R

期刊: AAAS: Science Advances: Table of Contents

标题: 电场限制合成单原子TiOxCy电催化膜

英文标题: Electric field–confined synthesis of single atomic TiOxCy electrocatalytic membranes

链接: https://www.science.org/doi/abs/10.1126/sciadv.ads7154?af=R

期刊: bioRxiv Subject Collection: Bioinformatics

标题: SM3DD与分段主成分分析：一种解释3D空间转录组学的综合方法

英文标题: SM3DD with Segmented PCA: A Comprehensive Method for Interpreting 3D Spatial Transcriptomics

链接: https://www.biorxiv.org/content/10.1101/2025.04.17.649456v1?rss=1

期刊: bioRxiv Subject Collection: Bioinformatics

标题: 利用蛋白质语言模型对新型细菌进行全基因组预测细菌致病能力的PathogenFinder2

英文标题: Whole-genome prediction of bacterial pathogenic capacity on novel bacteria using protein language models, with PathogenFinder2

链接: https://www.biorxiv.org/content/10.1101/2025.04.12.648497v1?rss=1

期刊: bioRxiv Subject Collection: Bioinformatics

标题: DTractor通过整合深度神经网络、迁移学习和矩阵分解，增强空间转录组学中的细胞类型去卷积

英文标题: DTractor enhances cell type deconvolution in spatial transcriptomics by integrating deep neural networks, transfer learning, and matrix factorization

链接: https://www.biorxiv.org/content/10.1101/2025.04.12.648541v1?rss=1